Antibody responses to heat-killed, phenol preserved parenteral typhoid vaccine.

The heat-killed, phenolized parenteral typhoid vaccine was tested in informed volunteers. Assessment for its immunogenicity was performed using Widal test and enzyme-linked immunosorbent assay (ELISA). The anti-H antibody, which is a marker of the vaccine antigenicity peaked at one month after the vaccination and appeared throughout the one year course of the study.

An epidemiological study of lung functions and hearing acuity in Singapore firemen.

This study was conducted on 506 firemen in Singapore. Interviews, pulmonary function tests and audiometry were conducted. With regard to pulmonary function, the results showed that forced vital capacity (FVC) increased up to the age of 25-30 years for both Chinese and Malays.

Antibody responses in cholera patients.

Haemagglutinating, vibriocidal and mouse protective antibody responses in cholera patients were found to be maximum on the 7th day of admission. The mouse protective antibody on the first day at the hospital was lower than those of human volunteers. The circulating antibodies in the patients declined to normal levels or lower than normal before 3 months after the acute onset.

Assessment of antibody responses and protective immunity in cholera vaccinated subjects.

Cross-reactive antibody responses were assessed in volunteers vaccinated with classical Inaba and Ogawa cholera vaccines. The El Tor, Ogawa vibrios, the most often biotype, and serotype found to be the causative agent of cholera in Thailand, or their product were used throughout the in vitro and in vivo tests. The test involved were the passive hemagglutination test, vibriocidal tests and the mouse protection test.