Publications by authors named "W Paul Williams"
PDA stenting is increasingly utilized for patients with ductal-dependent pulmonary blood flow. Predicting optimal stent length prior to and during the intervention remains a challenge. The utility of pre-catheterization computed tomography angiography (CTA) to predict stent length was evaluated.
View Article and Find Full Text PDFWhat we can learn about Mars from the magnetism of returned samples.
Proc Natl Acad Sci U S A
January 2025
The Red Planet is a magnetic planet. The Martian crust contains strong magnetization from a core dynamo that likely was active during the Noachian period when the surface may have been habitable. The evolution of the dynamo may have played a central role in the evolution of the early atmosphere and the planet's transition to the current cold and dry state.
View Article and Find Full Text PDFArticle Synopsis
- Understanding the evolution of genomic variation is essential for creating effective conservation strategies for threatened species, focusing on connectivity, demographic changes, and environmental adaptation.
- The study analyzed genomic variation in Fraxinus latifolia, a riparian tree facing threats from the invasive emerald ash borer, by sequencing over 1000 individuals from 61 populations.
- Results showed strong population structure and low genetic diversity, suggesting that this patchy distribution could hinder the species' long-term evolutionary potential, underscoring the importance of conserving genomic diversity for future restoration efforts.
Aims: Polyethylene glycol (PEG) is used in many applications including drug development. Due to exposure to environmental products, there is a high prevalence of preexisting anti-PEG antibodies in the global human population. The presence of anti-PEG antibodies is a concern for potentially reducing the efficacy of therapeutics after administration and represents a risk of safety events after exposure to PEGylated drug products.
View Article and Find Full Text PDFEvolving concern: Late outcomes after repair of transposition of the great arteries.
J Thorac Cardiovasc Surg
November 2024
Article Synopsis
- - The study evaluated the survival rates and need for re-operation in children who had surgery for transposition of great arteries (TGA) from 1990 to 2019, finding a strong 30-year survival rate of 92% and a low in-hospital death rate of 3.8%.
- - Most patients (94%) underwent arterial switch operations, with 82% being free from cardiac re-operations 30 years post-surgery. Re-operation rates were highest in the first 2 years, then decreased for 18 years, followed by an increase after 20 years.
- - Late complications were noted, particularly a concerning rise in neo-aortic valve and root re-operations after 17 years,