Publications by authors named "W Palinski"
Genomic-based precision medicine has not only improved tumour therapy but has also shown its weaknesses. Genomic profiling and mutation analysis have identified alterations that play a major role in sarcoma pathogenesis and evolution. However, they have not been sufficient in predicting tumour vulnerability and advancing treatment.
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- Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, and this study explores targeting the interaction between mitochondria and lysosomes as a new treatment method using patient-derived organoids.
- Researchers found that the overexpression of the Purinergic receptor 4 (P2XR4) in ccRCC affects mitochondrial activity, leading to increased cellular stress and eventual cell death, which highlights P2XR4 as a potential therapeutic target.
- Inhibiting P2XR4 showed promising results in reducing tumor size and increasing sensitivity in patient-derived organoids and xenograft models, suggesting that targeting this receptor may improve treatment outcomes for patients with ccRCC.
Aims: Elevated maternal cholesterol during pregnancy (MCP) enhances atherogenesis in childhood, but its possible impact on acute myocardial infarction (AMI) in adults is unknown.
Methods And Results: We retrospectively evaluated 310 patients who were admitted to hospital and whose MCP data were retrievable. Eighty-nine AMI patients with typical chest pain, transmural infarction Q-waves, elevated creatinine kinase, and 221 controls hospitalized for other reasons were identified.
The tumor microenvironment modulates cancer growth. Extracellular vesicles (EVs) have been identified as key mediators of intercellular communication, but their role in tumor growth is largely unexplored. Here, we demonstrate that EVs from sarcoma patients promote neoangiogenesis via a purinergic X receptor 4 (P2XR4) -dependent mechanism in vitro and in vivo.
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