Publications by authors named "W P Witjes"
Background And Objective: A survival benefit was demonstrated for patients with low-volume synchronous metastatic hormone-sensitive prostate cancer (mHSPCa) when local radiotherapy to the prostate was added to androgen deprivation therapy. This study aims to determine the incidence of prostate cancer-related events and treatments in those who received and those who did not receive external beam radiotherapy for mHSPCa.
Methods: The HORRAD trial is a multicentre randomised controlled trial recruiting originally 432 patients with mHSPCa diagnosed between 2004 and 2014.
Article Synopsis
- - The SATURN registry, a European multicenter study, aims to evaluate the effectiveness of surgical devices for treating male stress urinary incontinence, focusing on cure rates during a 10-year follow-up, with 1-year results currently reported.
- - The study involved 1,046 male patients, primarily post-radical prostatectomy, using various implants like AMS800 and Advance, and showed varying self-reported continence rates—ranging from 11% to 76% depending on the device, with 32% of patients still experiencing incontinence after one year.
- - Patient-reported outcomes indicated improvements in quality of life, but a notable percentage of patients required revisions of their devices, suggesting complications remained a concern
Article Synopsis
- - Surgery for male incontinence with artificial urinary sphincters and slings (SATURN) is an observational study aimed at gathering data on male stress urinary incontinence surgeries across various European centers.
- - The registry will assess both short- and long-term outcomes of these surgeries, focusing on their effectiveness and how they affect patients' quality of life.
- - By collecting this prospective data, the study aims to improve understanding and treatment strategies for male urinary incontinence.
Quality of Life in Patients with High-grade Non-muscle-invasive Bladder Cancer Undergoing Standard Versus Reduced Frequency of Bacillus Calmette-Guérin Instillations: The EAU-RF NIMBUS Trial.
Eur Urol Open Sci
October 2023
Background: Adverse events induced by intravesical bacillus Calmette-Guérin (BCG) to treat high-grade non-muscle-invasive bladder cancer (NMIBC) often lead to treatment discontinuation. The EAU-RF NIMBUS trial found a reduced number of standard-dose BCG instillations to be inferior with the standard regimen. Nonetheless, it remains important to evaluate whether patients in the reduced BCG treatment arm had better quality of life (QoL) due to a possible reduction in toxicity or burden.
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