Publications by authors named "W P Patterson"

Background: Patients with cancer routinely undergo genomic tumor sequencing, a component of molecular profiling (MP), to better characterize their cancer and identify potential targetable alterations. Targeted treatments potentially confer higher response rates and better efficacy. With increasing complexity, patients may require detailed explanations of MP results.

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Introduction: Regional anesthesia is frequently used for upper limb surgeries and postoperative pain control. Different approaches to brachial plexus blocks are similarly effective but may differ in the frequency and severity of iatrogenesis. We, therefore, examined large-scale registry data to explore the risks of typical complications among different brachial plexus block sites for regional anesthesia.

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Introduction: Human milk contains human milk oligosaccharides (HMOs) and microRNAs (miRNAs), which are key bioactive components. HMOs are indigestible carbohydrates that impact infant growth and development. miRNAs are small, non-coding RNAs that regulate post-transcriptional gene expression.

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Article Synopsis
  • The study investigates the presence of tDRs (tissue-specific RNAs) in human milk extracellular vesicles (EVs) and how they relate to various maternal factors like body mass index, age, and diet among a Latina population.
  • The research involved sequencing small RNAs from 109 milk samples collected one month postpartum and analyzing their associations with maternal characteristics using statistical models.
  • Results showed 338 tDRs, with 113 common across all samples, linked to factors such as the time of milk collection, breastfeeding patterns, and the mother's dietary inflammatory index, highlighting the potential influence of these variables on tDR expression in breast milk.
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Our systematic review and meta-analysis of 40 studies ( = 3,905,559) identified gastric acid suppressants, recent hospitalization, antibiotic exposure, and certain comorbidities as independent predictors of healthcare-associated infection (HA-CDI) among adult inpatients. Targeted antibiotic stewardship and judicious use of gastric acid suppressants can reduce the incidence of HA-CDI.

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