Publications by authors named "W P PURCELL"
Climate change and related pollution and environmental damage are an urgent focus for public health physicians. Curricular content is increasing in medical schools, but to date, only pediatrics has published guidance for residency education. To survey program directors of Accreditation Council for Graduate Medical Education preventive medicine specialties (public health and preventive medicine [PHPM], occupational and environmental medicine [OEM], and aerospace medicine [AM]) for current teaching on climate and health issues.
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- - The study investigated the safety and effectiveness of combining alisertib and sapanisertib in patients with difficult-to-treat solid tumors, focusing on pancreatic adenocarcinoma.
- - A total of 31 patients were treated, and while similar side effects to previous studies were noted, only one patient with breast cancer showed a significant improvement, and pancreatic cancer patients had modest treatment responses.
- - The findings suggest that targeting proteins involved in cell cycle regulation (Aurora A kinase) and tumor growth (mTOR) had limited overall clinical impact, but responses varied based on tumor characteristics and patient treatment history.
Article Synopsis
- - A 58-year-old woman experienced progressive visual loss after taking topiramate for migraines over 3-4 years, reporting issues like light adaptation difficulty and color vision problems.
- - Her visual acuity was severely diminished, and tests such as optical coherence tomography and electroretinogram revealed abnormalities consistent with retinal damage.
- - Extensive medical testing ruled out other potential causes, suggesting that her condition was likely induced by the long-term use of topiramate.
Higher education (HE) matters to the global struggle to combat climate change. Research builds knowledge and informs climate solutions. Educational programmes and courses upskill current and future leaders and professionals to tackle the systems change and the transformation needed to improve society.
View Article and Find Full Text PDFBackground: Cancer-related fatigue (CRF) is one of the most reported and functionally limiting symptoms experienced by individuals living with and beyond cancer. Exercise is effective at reducing CRF, though currently it is not possible to predict the magnitude and time course of improvement for an individual participating in an exercise program.
Objective: To develop a reference chart of CRF improvement for individuals participating in a 3-month cancer-specific exercise program.