Efficacy of a stable broadly protective subunit vaccine platform against SARS-CoV-2 variants of concern.

The emergence and ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the need for rapid vaccine development platforms that can be updated to counteract emerging variants of currently circulating and future emerging coronaviruses. Here we report the development of a "train model" subunit vaccine platform that contains a SARS-CoV-2 Wuhan S1 protein (the "engine") linked to a series of flexible receptor binding domains (RBDs; the "cars") derived from SARS-CoV-2 variants of concern (VOCs). We demonstrate that these linked subunit vaccines when combined with Sepivac SWE™, a squalene in water emulsion (SWE) adjuvant, are immunogenic in Syrian hamsters and subsequently provide protection from infection with SARS-CoV-2 VOCs Omicron (BA.

Politicians' high-status signals make less-educated citizens more supportive of aggression against government: A video-vignette survey experiment.

Various branches of the literature suggest that exposure to the high-status appearances and lifestyles of politicians in contemporary "diploma democracies" affects the attitudes and behavior of less-educated citizens because it confronts them with their lower status in the political domain. Informed by this, we theorize that such exposure inspires docility (a lower subjective social status, weaker feelings of political entitlement) and revolt (anger, more support for aggression against government). To investigate this, we conducted an original, pre-registered, video-vignette survey experiment among a representative sample of the Dutch population.

Factors influencing migration of short-finned eels (Anguilla australis) over 3 years from a wetland system, Lake Condah, south-east Australia, downstream to the sea.

Anguillid eel populations are under threat globally. A particularly vulnerable life-cycle stage is the migration of mature adult eels downstream from freshwater habitats through estuaries into the sea to spawn. This study investigated the factors associated with downstream migration of the short-finned eel Anguilla australis (Richardson 1841) from a coastal wetland (Lake Condah) in south-east Australia, using acoustic telemetry.

Sugar tax and product reformulation proposals reduce the perceived legitimacy of health-promotion institutions: a randomized population-based survey experiment.

Background: Structural nutrition interventions like a sugar tax or a product reformulation are strongly supported among the public health community but may cause a considerable backlash (e.g. inspiring aversion to institutions initiating the interventions among citizens).

What do stances on immigrants' welfare entitlement mean? Evidence from a correlational class analysis.

Recent in-depth qualitative research indicates that different people ascribe different meanings to their apparently similar stances on immigrants' entitlement to welfare. We are the first to investigate such variation quantitatively among the public-at-large, applying the novel method Correlational Class Analysis to an original survey fielded among a representative sample in the Netherlands (n = 2138). We uncover five ways of looking at immigrants' entitlement to welfare, each including both people who oppose that entitlement and those who support it.