Publications by authors named "W P Gordon"
Rationale: Chronic () airway infection is common and a key contributor to diminished lung function and early mortality in persons with cystic fibrosis (PwCF). Risk factors for chronic among PwCF include cystic fibrosis transmembrane conductance regulator genotype, genetic modifiers, and environmental factors. Intensive antibiotic therapy and highly effective modulators do not eradicate in most adolescents and adults with cystic fibrosis.
View Article and Find Full Text PDFResearch on visually driven behavior in anurans has often focused on Dendrobatoidea, a clade with extensive variation in skin reflectance, which is perceived to range from cryptic to conspicuous coloration. Because these skin patterns are important in intraspecific and interspecific communication, we hypothesized that the visual spectral sensitivity of dendrobatids should vary with conspecific skin spectrum. We predicted that the physiological response of frog retinas would be tuned to portions of the visible light spectrum that match their body reflectance.
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- A study evaluated the safety and efficacy of endovascular thrombectomy in patients with acute large-vessel occlusion and tandem lesions, focusing on those with low (0-5) and high (6-10) Alberta Stroke Program Early Computed Tomography Scores (ASPECTS).
- The analysis included 691 patients, revealing that those with low ASPECTS had significantly lower odds of achieving a favorable functional outcome (mRS 0-2) and higher odds of suffering symptomatic intracranial hemorrhage compared to those with high ASPECTS.
- The researchers concluded that endovascular thrombectomy may lead to poorer functional recovery in patients with tandem lesions and low ASPECTS, particularly in the
Article Synopsis
- Notch is important for development and diseases, leading researchers to create inhibitors using small molecules and antibodies.* -
- A novel nanobody was developed to inhibit Notch signaling, showing effectiveness in laboratory assays despite a low affinity for the Notch target.* -
- By linking the nanobody to a toxin-derived membrane domain, researchers improved its potency, successfully inhibiting cancer cell proliferation similar to existing Notch blockers.*
Article Synopsis
- The dystrophin-glycoprotein-complex (DGC), which connects the cell's internal structure to its external environment, is crucial for muscle function, and its disruption is linked to diseases like muscular dystrophy.
- Recent research focused on understanding how matrix-metalloproteinases (MMPs) can cleave dystroglycan, a key protein in the DGC, and how this might contribute to such diseases.
- By analyzing the structure of dystroglycan, scientists discovered how its unique C-terminal extension regulates MMP cleavage, which could help clarify mechanisms behind DGC disruption in muscular dystrophy.