Publications by authors named "W P Anthony"
Background: Reactive case detection (RACD) for malaria control has been found effective in low transmission settings, but its impact and cost-effectiveness in moderate-to-high transmission settings are unknown. We conducted an economic evaluation alongside an empirical trial of a modified RACD strategy (1,7-mRCTR) in three moderate-to-high malaria transmission districts in Tanzania.
Methods: The costs and cost savings associated with the intervention relative to passive case detection alone were estimated in the study sites of Kilwa, Kibiti, and Rufiji districts in Tanzania from 2019-2021.
Article Synopsis
- Soil microbiomes are complex and varied communities of microbes, and large-scale metagenomic analysis is generating significant challenges in understanding their unique genetic makeups.
- Advances in technology allow for the collection of extensive sequence data, but many soil samples still lack detailed characterization due to the sheer number of different taxa present.
- Establishing publicly available databases of soil Meta-Genome Assembled Genomes (MAGs) could greatly enhance our understanding of soil microbiomes, facilitating research without the need for advanced computational skills or resources.
Increased triacylglycerol production in Rhodococcus opacus by overexpressing transcriptional regulators.
Biotechnol Biofuels Bioprod
June 2024
Lignocellulosic biomass is currently underutilized, but it offers promise as a resource for the generation of commercial end-products, such as biofuels, detergents, and other oleochemicals. Rhodococcus opacus PD630 is an oleaginous, Gram-positive bacterium with an exceptional ability to utilize recalcitrant aromatic lignin breakdown products to produce lipid molecules such as triacylglycerols (TAGs), which are an important biofuel precursor. Lipid carbon storage molecules accumulate only under growth-limiting low nitrogen conditions, representing a significant challenge toward using bacterial biorefineries for fuel precursor production.
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- Progress in malaria control has stalled, prompting the need for innovative surveillance and response strategies in Africa, specifically through the 1,7-malaria Reactive Community-Based Testing and Response (1,7-mRCTR) approach tested in Tanzania.
- The study showed that 244,771 community-based malaria rapid tests were conducted over two years, resulting in a significant decline in malaria prevalence from 27.4% to 11.7% in intervention areas, with a notable 4.5% decrease attributed to the 1,7-mRCTR strategy.
- Despite challenges such as interruptions from the COVID-19 pandemic, the findings suggest that the 1,7-mRCTR approach is effective in reducing malaria incidence, particularly
is a bacterium that has a high tolerance to aromatic compounds and can produce significant amounts of triacylglycerol (TAG). Here, we present iGR1773, the first genome-scale model (GSM) of PD630 metabolism based on its genomic sequence and associated data. The model includes 1773 genes, 3025 reactions, and 1956 metabolites, was developed in a reproducible manner using CarveMe, and was evaluated through Metabolic Model tests (MEMOTE).
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