Omics of endothelial cell dysfunction in sepsis.

During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in increased permeability and excessive recruitment of leukocytes. Vascular endothelial cells share many common properties but have organ-specific phenotypes with unique structure and function. Thus, therapies directed against endothelial cell phenotypes are needed to address organ-specific endothelial cell dysfunction.

Rapid induction of therapeutic hypothermia using convective-immersion surface cooling: safety, efficacy and outcomes.

Therapeutic hypothermia has become an accepted part of post-resuscitation care. Efforts to shorten the time from return of spontaneous circulation to target temperature have led to the exploration of different cooling techniques. Convective-immersion uses a continuous shower of 2 degrees C water to rapidly induce hypothermia.

Successful defibrillation in water: a preliminary study.

Mild hypothermia (32-34 deg C) treatment alleviates vital organ damage after cardiac arrest. A new cooling device, the Thermosuit operates by applying of a thin layer of water directly to the body surface. Hypothermic patients may experience sequential fibrillation.

External cardiac defibrillation during wet-surface cooling in pigs.

Objective: During surface cooling with ice-cold water, safety and effectiveness of transthoracic defibrillation was assessed.

Methods: In a pig ventricular fibrillation cardiac arrest model, once (n = 6), defibrillation was done first in a dry and then in a wet condition using the ThermoSuit System (Life Recovery Systems, HD, LLC, Kinnelon, NJ), which circulates a thin layer of ice-cold water (approximately 4 degrees C) over the skin surface. Another time (n = 6), defibrillation was done first in a wet and then in a dry condition.

Fractal analysis of bone X-ray tomographic microscopy projections.

Fractal analysis of bone X-ray images has received much interest recently for the diagnosis of bone disease. In this paper, we propose a fractal analysis of bone X-ray tomographic microscopy (XTM) projections. The aim of the study is to establish whether or not there is a correlation between three-dimensional (3-D) trabecular changes and two-dimensional (2-D) fractal descriptors.