Publications by authors named "W O Tarnow-Mordi"
Introduction: We showed in a phase II randomised controlled trial (RCT) that oral sildenafil citrate in term labour halved operative birth for fetal distress. We outline the protocol for a phase III RCT (can ntrapartum ildnafil safely vert the isks of ontraction-induced ypoxia? (iSEARCH)) of 3200 women in Australia to assess if sildenafil citrate reduces adverse perinatal outcomes related to intrapartum hypoxia.
Methods And Analysis: iSEARCH will enrol 3200 Australian women in term labour to determine whether up to three 50 mg oral doses of sildenafil citrate versus placebo reduce the relative risk of a primary composite end point of 10 perinatal outcomes potentially related to intrapartum hypoxia by 35% (from 7% to 4.
Article Synopsis
- - The RidStress 2 trial is a phase III study investigating whether maternal oral sildenafil citrate during labor can reduce the need for emergency caesarean sections due to fetal distress in women with small for gestational age infants.
- - The trial involves 660 women and aims to determine the effect of sildenafil citrate on cesarean rates, along with assessing cost-effectiveness and long-term child neurodevelopment.
- - Ethics approval has been secured, and results will be shared through scientific presentations and publications, with the trial registered with relevant clinical trial authorities.
Background: Immediately after birth, the oxygen saturation is between 30 and 50%, which then increases to 85-95% within the first 10 min. Over the last 10 years, recommendations regarding the ideal level of the initial fraction of inspired oxygen (FiO) for resuscitation in preterm infants have changed from 1.0, to room air to low levels of oxygen (< 0.
View Article and Find Full Text PDFObjective: To compare cost-effectiveness of oral sildenafil citrate, administered after onset of labor, with standard care to health system funders in the UK and Australia.
Methods: We conducted a modeled cost-effectiveness analysis, measuring costs and quality adjusted life years (QALYs), using a decision-analytic model covering onset of labor to 1 month post-birth. The relative risk of emergency cesarean section and operative vaginal birth was taken from a Phase 2 placebo controlled double blinded randomized control trial.
Article Synopsis
- The Australian Placental Transfusion Study looked at how long to wait before cutting the umbilical cord in babies, comparing waiting at least 60 seconds to waiting 10 seconds or less.
- The study found that waiting longer might help reduce the chances of babies dying or having disabilities by 17%.
- However, the results aren't super strong because a few missing data points could change things, so future studies should try to collect all important information to make the results more reliable.