Immunohistochemical expression of vascular endothelial growth factor (VEGF) and p53 in breast lesions.

Objective: Vascular endothelial growth factor (VEGF) is a leading factor for tumour angiogenesis and p53 protein is the product of a tumor suppressor gene. The main aim of the study was to assess the association of p53 protein with VEGF expression in breast carcinoma.

Materials And Methods: This was a retrospective study involving 66 invasive breast carcinomas, 66 normal breast tissues and 55 cases of usual ductal hyperplasia (UDH), obtained from the histopathology records.