Publications by authors named "W Nishie"
Epithelia consist of proliferating and differentiating cells that often display patterned arrangements. However, the mechanism regulating these spatial arrangements remains unclear. Here, we show that cell-cell adhesion dictates multicellular patterning in stratified epithelia.
View Article and Find Full Text PDFAutologous sweat-induced anaphylaxis and basophil activation test.
J Eur Acad Dermatol Venereol
November 2024
Article Synopsis
- Pemphigoid diseases involve the formation of blisters and autoantibodies that attack skin proteins like BP180, but the specific regions targeted by these antibodies are not fully understood.* -
- Researchers immunized mice with BP180 to create anti-BP180 antibodies and discovered that these antibodies target specific parts of BP180, particularly the intracellular and extracellular domains.* -
- The study found that certain antibodies reacted to new epitopes on BP180 that are similar to those found in human cases, with distinct antibody subclasses (IgG and IgM) indicating potential natural immune responses in mice.*
Article Synopsis
- Pemphigoid diseases, including mucous membrane pemphigoid (MMP), are autoimmune disorders that cause blistering, with autoantibodies targeting hemidesmosome molecules like collagen XVII and integrin a6/β4.
- Traditional detection methods for MMP autoantibodies face challenges due to their diverse profiles and low levels, prompting the need for improved systems.
- This study presents a new ELISA utilizing a native autoantigen complex isolated through CRISPR/Cas9 editing, demonstrating enhanced diagnostic performance with sensitivity at 70.9% and specificity at 86.7% compared to conventional methods.