Publications by authors named "W N Scott"
Pain is common among individuals with high Body Mass Index (BMI). This study investigated weight discrimination as a mediator of the longitudinal relationship between BMI and the presence of moderate/severe pain among adults from the English Longitudinal Study of Ageing (ELSA) cohort. ELSA is a longitudinal study of middle-aged and older adults living in England.
View Article and Find Full Text PDFPurpose: To investigate the association between epigenetic age acceleration and glaucoma progression.
Design: Retrospective cohort study.
Participants: 100 primary open-angle glaucoma (POAG) patients with fast progression and 100 POAG patients with slow progression.
Introduction: Recently, the O-6-methylguanine-DNA methyltransferase (MGMT) locus was proposed as influencing the risk of Alzheimer's disease (AD) in women who did not carry the apolipoprotein E ε4 allele. We examined an Amish founder population for any influence of genetic variation in and around the MGMT locus on the risk for dementia.
Methods: Genetic association was performed for single nucleotide polymorphisms (SNPs) surrounding the MGMT locus.
Novel active Trp- and Arg-rich antimicrobial peptides with high solubility and low red blood cell toxicity designed using machine learning tools.
Int J Antimicrob Agents
December 2024
Article Synopsis
- * Machine learning techniques were used to identify and rank potential non-hemolytic AMPs from two libraries of peptide sequences, leading to the synthesis and testing of 220 peptides against Methicillin-resistant Staphylococcus aureus (MRSA).
- * Six promising AMPs were further analyzed for their effectiveness against various bacteria and cancer cell lines, revealing a successful strategy for creating effective and safe antimicrobial agents, while also setting a foundation for future research and machine learning applications in peptide design.