Addressing STIs through managed care: opportunities in Medicaid and beyond.

The US is facing a growing epidemic of sexually transmitted infections (STIs), with over 2.5 million cases of chlamydia, gonorrhea, and syphilis reported in 2021 and again in 2022. This public health crisis disproportionately affects youth and racial and ethnic minority communities, exacerbating barriers to accessing sexual health services.

Effect of a dietary nutraceutical "STRUCTURE-Joint" on response of horses to intra-articular challenge with IL-1: implications for tissue adaptation to stress.

The purpose was to determine local (articular) and systemic effects of intra-articular interleukin-1 in horses supplemented with a dietary PUFA supplement [STRUCTURE-Joint ()]. Sixteen (16) healthy, mature, light breed horses were randomly assigned to diets containing 0 or 120 mL ( = 8 per group) of ST-J for 30 d. On days 0 (prior to beginning supplementation) and 27, recombinant equine interleukin-1β () (75 ng) was injected into the left or right intercarpal joint to induce mild, transient synovitis.

Microbial metabolism disrupts cytokine activity to impact host immune response.

Host-pathogen interactions are shaped by the metabolic status of both the host and pathogen. The host must regulate metabolism to fuel the immune response, while the pathogen must extract metabolic resources from the host to enable its own survival. In this study, we focus on the metabolic interactions of with .