Publications by authors named "W N Kinney"
Article Synopsis
- ENT-03 is a newly discovered compound in newborn mice that helps regulate energy and metabolism by lowering blood glucose levels, especially in obese and diabetic mice.
- In experiments, treatment with ENT-03 led to significant weight loss and normalization of biochemical parameters following decreased food intake.
- The compound targets specific brain regions linked to appetite control and is being tested in clinical trials for potential use in treating type 2 diabetes and obesity.*
Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential.
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- Implementation of primary HPV testing in the U.S. is slow, largely due to concerns about its sensitivity compared to cotesting methods, which combine HPV and cytology testing.
- A study of various populations showed that cotesting led to more laboratory tests and colposcopies than primary HPV testing, indicating a higher burden on healthcare resources.
- As the prevalence of cervical issues decreased, the detection of significant conditions through cotesting became less advantageous, suggesting that primary HPV testing may provide a better balance between benefits and risks than cotesting.
KLS-13019 was reported previously to reverse paclitaxel-induced mechanical allodynia in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies demonstrated that paclitaxel-induced increases in inflammatory markers (GPR55, NLRP3, and IL-1β) of dorsal root ganglion (DRG) cultures were shown to be reversed by KLS-13019 treatment. The mechanism of action for KLS-13019-mediated reversal of paclitaxel-induced neuroinflammation now has been explored using GPR55 siRNA.
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