Publications by authors named "W N Kernan"
Article Synopsis
- The "2024 Guideline for the Primary Prevention of Stroke" updates the previous 2014 guidelines, providing new strategies for preventing strokes in individuals without a prior history.
- A thorough review of relevant literature from various databases was conducted to inform these updated recommendations, ensuring they are based on the latest research.
- The guidelines emphasize the preventability of strokes and include new sex-specific recommendations, aligning with the American Heart Association's Life's Essential 8, while also updating previous recommendations based on recent research findings.
Importance: Stroke secondary prevention trials have disproportionately enrolled participants with mild or no disability. The impact of this bias remains unclear.
Objective: To investigate the association between poststroke disability and the rate of recurrent stroke during long-term follow up.
Background: The implementation of preventive therapies among patients with stroke remains inadequately explored, especially when compared with patients with myocardial infarction (MI), despite sharing similar vascular risk profiles. We tested the hypothesis that participants with a history of stroke have a worse cardiovascular prevention profile in comparison to participants with MI.
Methods And Results: In cross-sectional analyses within the UK Biobank and All of Us Research Program, involving 14 760 (9193 strokes, 5567 MIs) and 7315 (2948 strokes, 4367 MIs) participants, respectively, we evaluated cardiovascular prevention profiles assessing low-density lipoprotein (<100 mg/dL), blood pressure (systolic, <140 mm Hg; and diastolic, <90 mm Hg), statin and antiplatelet use, and a cardiovascular prevention score that required meeting at least 3 of these criteria.
Background: Vascular brain injury (VBI) may be an under-recognised contributor to mobility impairment. We examined associations between MRI VBI biomarkers and impaired mobility.
Methods: We separately analysed Atherosclerosis Risk in Communities (ARIC) and UK Biobank (UKB) study cohorts.