Publications by authors named "W N Hustinx"
Time for first antibiotic dose is not predictive for the early clinical failure of moderate-severe community-acquired pneumonia.
Eur J Clin Microbiol Infect Dis
August 2009
The time to first antibiotic dose (TFAD) has been mentioned as an important performance indicator in community-acquired pneumonia (CAP). However, the advice to minimise TFAD to 4 hours (4 h) is only based on database studies. We prospectively studied the effect of minimising the TFAD on the early clinical outcome of moderate-severe CAP.
View Article and Find Full Text PDFObjective: To determine the effect of oral decontamination with either chlorhexidine (CHX, 2%) or the combination chlorhexidine-colistin (CHX-COL, 2%-2%) on the frequency and the time to onset of ventilator-associated pneumonia in Intensive Care patients.
Design: Double blind, placebo-controlled, multicentre, randomised trial.
Methods: Consecutive ICU patients needing at least 48 h of mechanical ventilation were enrolled in a randomized trial with 3 arms: CHX, CHX-COL, and placebo (PLAC).
Objective: To compare an early switch from intravenous to oral antibiotics with the standard intravenous therapy in patients admitted to hospital with severe community acquired pneumonia.
Design: Multicentre randomised prospective trial with follow-up at 28 days.
Method: Patients with severe pneumonia who were admitted to hospital were randomised for 7 days intravenous antibiotic therapy (control group) or for an early switch to oral antibiotic therapy after 3 days of intravenous antibiotic therapy (intervention group).
Objectives: To compare the effectiveness of an early switch to oral antibiotics with the standard 7 day course of intravenous antibiotics in severe community acquired pneumonia.
Design: Multicentre randomised controlled trial.
Setting: Five teaching hospitals and 2 university medical centres in the Netherlands.