Breast pericytes: a newly identified driver of tumor cell proliferation.

Introduction: Effective treatment of breast cancer remains a formidable challenge, partly due to our limited understanding of the complex microenvironmental factors that contribute to disease pathology. Among these factors are tissue-resident perivascular cells, which play crucial roles in shaping vascular basement membranes, maintaining vessel integrity, and communicating with adjacent endothelial cells. Despite their essential functions, perivascular cells have been relatively overlooked.

Examining Social-Ecological Factors in Developing the Louisville Metro Department of Public Health and Wellness Syringe Exchange Program.

Amid an opioid epidemic and increasing HIV and hepatitis C virus (HCV) concerns, the Louisville Metro Department of Public Health and Wellness developed syringe exchange programming (SEP) to reduce HIV and HCV transmission, increase linkage to health care, and provide health education to clients in Louisville, Kentucky. We describe organizational, community, and policy factors contributing to SEP development. Approximately 8000 clients received SEP services from June 2015 to December 2016.

Reprocessing unsatisfactory ThinPrep papanicolaou tests using a modified SurePath preparation technique.

Background: The frequency of unsatisfactory gynecologic specimens has increased in the study laboratory over the last few years due to the advent of personal lubricants. Similarly, lysed blood, protein, and necrotic debris present a challenge in terms of negative cell transference caused by a clogged filter. In the current study, the authors evaluated the potential use of a modified SurePath reprocessing technique to decrease the frequency of unsatisfactory specimens.

Clinical significance of reporting benign-appearing endometrial cells in Pap tests in women aged 40 years and over.

Objective: To determine the clinical significance of reporting benign-appearing endometrial cells on Pap tests from women > or = 40 years.

Study Design: Pap tests from 149 women demonstrating cytologically benign endometrial cells with histologic follow-up within 12 months were included. Age, menopausal status, hormone replacement therapy (HRT) status, abnormal uterine bleeding (AUB), number of children and information from subsequent endometrial sampling were recorded when available.

Nuclear size, shape, and density in endometrial carcinoma: relationship to survival at over 5 years of follow-up. Does analyzing only cells occupying the G0-G1 peak add useful information?

Objective: The authors, using image analysis, previously demonstrated nuclear size and summed optical density to be independent prognostic indicators of recurrence in patients with endometrial carcinoma. The same tumors were analyzed by studying the optical features in the G0-G1 peak to see if this changed the values found as well as their importance as prognostic features at greater than 5 years of follow-up.

Methods: Tumors from 74 consecutive patients, surgically treated, with endometrial cancer, were evaluated.