Publications by authors named "W Mulley"
Background: Adoptive transfer of autologous regulatory T cells (Tregs) is a promising therapeutic strategy aimed at enabling immunosuppression minimization following kidney transplantation. In our phase 1 clinical trial of Treg therapy in living donor renal transplantation, the ONE Study (ClinicalTrials.gov: NCT02129881), we observed focal lymphocytic infiltrates in protocol kidney transplant biopsies that are not regularly seen in biopsies of patients receiving standard immunosuppression.
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- Infection and rejection pose serious challenges for transplant patients, making it crucial for clinicians to effectively balance the risks associated with these complications.
- Current diagnostic strategies for assessing immune status and infection or rejection risks are imprecise, often relying on both immune and non-immune markers, complicating patient care.
- Emerging biomarkers like donor-derived cell-free DNA and urinary chemokines show promise in predicting rejection risk, potentially reducing the need for invasive biopsies and allowing for better management of immunosuppression to optimize patient outcomes.
Background: Recurrent glomerulonephritis (GN) is an important cause of allograft loss after transplantation when GN is the primary cause of kidney failure. Retransplantation after allograft loss from recurrent disease requires careful consideration. We aimed to determine the probability of relisting and the risk of allograft loss after retransplantation in recipients with prior allograft loss from recurrent GN.
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- * Researchers analyzed data from 642 allograft failures, finding that various forms of rejection accounted for the majority (47.5%) of cases, with chronic antibody-mediated rejection being the most common cause.
- * The findings suggest a need for better strategies to manage immune responses and more research on less understood causes of kidney transplant failure, particularly undifferentiated interstitial fibrosis and tubular atrophy.
Background: Disparities in aspects of chronic kidney disease progression and management exist for patients from culturally and linguistically diverse (CALD) backgrounds, including with treatment and outcomes for kidney transplantation.
Objective: This study aimed to explore factors that impact kidney transplant outcomes from the perspective of kidney transplant recipients (KTRs) from CALD backgrounds and their family caregivers.
Methods: A descriptive qualitative design was utilised.