Pt single atoms promoting the construction of asymmetric double sites to achieve highly selective photoreduction of CO to ethylene.

In this work, Pt single atoms (SAs) were engineered on the surface of CdInS (CIS) to trigger abundant generation and stable existence of sulfur vacancies (S). Through quasi in situ X-ray photoelectron spectroscopy (XPS) and work function analysis, the photogenerated electrons are first captured by Pt SAs and S, and then transferred from Pt SAs to S, ultimately increasing the electron density of S. Meanwhile, S have significant advantages in adsorbing CO molecules.

Pharmacokinetics of cisplatin in the systemic versus hyperthermic intrathoracic or intraperitoneal chemotherapy.

Objective: To compare the pharmacokinetics and adverse effects of cisplatin administered via intravenous infusion for systemic chemotherapy (SC) versus injection into the perfusate during hyperthermic intrathoracic chemotherapy (HITHOC) or hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods: Total 60 patients who received SC, HITHOC, or HIPEC in the Department of Oncology, Tangdu Hospital, were enrolled into this study. After administering same dose of cisplatin (40 mg) via either intravenous infusion (SC group) or injection into the perfusate during the HITHOC or HIPEC procedure, concentration of cisplatin in the plasma as well as in the hyperthermic perfusate at various time points was quantified by HPLC analysis.

Down-regulation of HSPB1 and MGST1 promote ferroptosis and impact immune infiltration in diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) is a leading cause of death in diabetic patients. Current therapies do not adequately resolve this problem and focus only on the optimal level of blood glucose for patients. Ferroptosis plays an important role in diabetes mellitus and cardiovascular diseases.

Ultra-Broadband Perfect Absorbers Based on Biomimetic Metamaterials with Dual Coupling Gradient Resonators.

Ultra-broadband metamaterial absorbers can achieve near-perfect absorption of omnidirectional electromagnetic waves, crucial for light utilization and manipulation. Traditional ultra-broadband metamaterials rely on the superposition of different resonator units either in the plane or in perpendicular directions to broaden absorption peaks. However, this approach is subject to quantity restrictions and complicates the fabrication process.

Ketogenic Diet Reduces Age-Induced Chronic Neuroinflammation in Mice.

The ketone body beta-hydroxybutyrate (BHB) is an acidic energy metabolite that is synthesized during periods of fasting or exercise. Our previous study demonstrated that an every other week cyclic ketogenic diet (Cyclic KD), which induces blood BHB levels similar to those observed during fasting, reduces midlife mortality and improves memory in aging mice. In addition to its canonical role as an energy metabolite, BHB regulates gene expression and inflammatory activation through non-energetic signaling pathways.