Publications by authors named "W Mousa"
Article Synopsis
- Highly pathogenic avian influenza (HPAI) H5N1 has persisted in Egypt for nearly 20 years, significantly affecting poultry and public health, with Egypt being a key location for outbreaks in Africa.
- This study aimed to analyze spatiotemporal patterns of HPAI H5N1 to identify high-risk areas at the subdistrict level and develop targeted interventions.
- Results revealed that while Menofia wasn't the outbreak origin, rural areas showed increased risk, with urban areas experiencing lower outbreak densities, suggesting that urban centers could initially spread the virus, necessitating focused public health responses.
Article Synopsis
- Antibacterial resistance is a major health threat, highlighting the need for new antibiotic developments, particularly through antimicrobial peptides.* -
- This study focused on creating and testing new antimicrobial peptides based on lactomodulin, showing strong antibacterial effectiveness against both Gram-positive and resistant Gram-negative bacteria.* -
- The most active peptide demonstrated fast bactericidal effects by disrupting bacterial cell membranes, indicating its potential as a targeted antibacterial agent.*
The gut microbiome emerges as an integral component of precision medicine because of its signature variability among individuals and its plasticity, which enables personalized therapeutic interventions, especially when integrated with other multiomics data. This promise is further fueled by advances in next-generation sequencing and metabolomics, which allow in-depth high-precision profiling of microbiome communities, their genetic contents, and secreted chemistry. This knowledge has advanced our understanding of our microbial partners, their interaction with cellular targets, and their implication in human conditions such as inflammatory bowel disease (IBD).
View Article and Find Full Text PDFCancer immunotherapy has emerged as a transformative approach in oncology, utilizing the body's immune system to specifically target and destroy malignant cells. This review explores the scope and impact of various immunotherapeutic strategies, including monoclonal antibodies, chimeric antigen receptor (CAR)-T cell therapy, checkpoint inhibitors, cytokine therapy, and therapeutic vaccines. Monoclonal antibodies, such as Rituximab and Trastuzumab, have revolutionized treatment paradigms for lymphoma and breast cancer by offering targeted interventions that reduce off-target effects.
View Article and Find Full Text PDFSynthetic microbial communities, which simplify the complexity of natural ecosystems while retaining their key features, are gaining momentum in engineering and biotechnology applications. One potential application is the development of bioinoculants, offering an eco-friendly, sustainable solution to promote plant growth and increase resilience to abiotic stresses amidst climate change. A potential source for stress-tolerant microbes is those associated with desert plants, evolved and shaped by selective pressures to promote host health under harsh environmental conditions.
View Article and Find Full Text PDF