[The role of nicotine as a modulator of the activity of acid phosphotase and cathepsin D and L in the liver and kidney of mice].

To our knowledge, no reports on the impact of nicotine on the enzyme activity of the lysosomal system have been published yet. The study which is reported here is probably one of the first analyses of the models of lysosomal hydrolases of the liver and kidney of experimental mice which were exposed to various doses of nicotine. The aim of our experimental study was to analyze the impact of nicotine administered for 4 or 8 days in the dosage of 12 and 20 mg/kg body weight, respectively, on the activity of acid phosphatase and cathepsins D and L, i.