Publications by authors named "W Madani"
Article Synopsis
- Enterococci are bacteria primarily found in the gastrointestinal tract, but they can also affect other organs like the heart, liver, and kidneys, potentially leading to severe infections.
- Their ability to thrive in various environments is due to their metabolic flexibility, which helps them adapt and persist in different tissues.
- To transition from harmless residents to harmful pathogens, enterococci have developed strategies to overcome challenges like nutrient competition and the immune response, utilizing specific molecular pathways for adhesion and colonization.
Article Synopsis
- Chemotherapy dosing traditionally relies on patient weight and height, which often leads to significant variations in drug levels, potentially causing under- or overdosing.
- A new closed-loop drug delivery system, known as CLAUDIA, can automatically adjust drug infusion rates to maintain target drug concentrations in patients, regardless of their individual pharmacokinetics.
- Tests showed that CLAUDIA effectively kept the concentration of 5-fluorouracil within range, unlike conventional BSA-based dosing, and is also more cost-effective, with potential for rapid clinical implementation.
Efficacy and Safety of the Utilization of Dipeptidyl Peptidase IV Inhibitors in Diabetic Patients with Chronic Kidney Disease: A Meta-Analysis of Randomized Clinical Trials.
Moeber M Mahzari Muhannad Qirnas Alqirnas Moustafa S Alhamadh Faisal Alrasheed Abdulrahman Yousef Alhabeeb Wedad Al Madani
Diabetes Metab Syndr Obes
March 2024
Aim: To assess the efficacy and safety of Dipeptidyl Peptidase IV (DPP-4) inhibitors in patients with Type-2 Diabetes Mellitus (T2DM) and chronic kidney disease (CKD) using level 1 evidence.
Methods: The Cochrane and PubMed databases were searched from inception until January 1, 2022. RCTs that studied the efficacy and safety of DPP-4 inhibitors in diabetic patients with CKD were included.
Article Synopsis
- Postoperative ileus (POI) often causes extended hospital stays after abdominal surgery due to digestive tract paralysis, leading to symptoms like constipation and vomiting.
- Currently, treatments for POI are mainly supportive and not very effective, prompting the development of a new device called INSPIRE, which is an ingestible and self-propelling device designed to stimulate intestinal movement.
- In tests on swine models, the INSPIRE device significantly improved intestinal motility, with a 44% increase in normal cases and a 140% improvement in chemically induced ileus, drastically reducing the average passage time from 8.6 days to 2.5 days, making it a promising noninvasive treatment option for motility disorders.
Article Synopsis
- Pills are essential in medicine but can be hard to swallow, while liquid forms lack specific therapeutic targeting and controlled release.
- The study introduces liquid in situ-forming tough (LIFT) hydrogels, which create a gel in the stomach by mixing two solutions, allowing for a better drug delivery method.
- Tested in live rats and pigs, LIFT hydrogels are strong, safe, and effectively deliver drugs while protecting sensitive therapeutic enzymes and bacteria from stomach acid, potentially aiding patients who struggle with traditional medicine forms.