Publications by authors named "W M de Graaf"
Adverse health outcomes and health-related quality of life (HRQoL) among long-term adolescent and young adult (AYA) brain tumour survivors: results from the population-based SURVAYA study.
Support Care Cancer
January 2025
Purpose: Adolescent and young adult (AYA) malignant brain tumour (BT) survivors are at risk of adverse health outcomes, which may impact their health-related quality of life (HRQoL). This study aimed to investigate the (1) prevalence of physical and psychological adverse health outcomes, (2) the HRQoL, and (3) the association of adverse health outcomes and HRQoL among long-term AYA-BT survivors. Adverse health outcomes and HRQoL were compared to other AYA cancer (AYAC) survivors.
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- The study aimed to investigate imaging biomarkers for tumor response in patients with intermediate/high-grade soft tissue sarcomas (STS) following neoadjuvant radiotherapy (nRT), focusing on changes in imaging and pathology.
- The analysis involved 107 patients, measuring tumor characteristics like diameter, volume, and signal intensity before and after treatment, and correlated these with pathological outcomes such as necrosis and viable cell percentage using statistical methods.
- Results showed a low rate of complete tumor response, with specific subtypes like myxoid liposarcoma and undifferentiated pleomorphic sarcoma exhibiting significant changes in tumor size and signal intensity related to necrosis and fibrosis post-radiotherapy.
Purpose: Research on rare diseases and atypical health care demographics is often slowed by high interparticipant heterogeneity and overall scarcity of data. Synthetic data (SD) have been proposed as means for data sharing, enlargement, and diversification, by artificially generating real phenomena while obscuring the real patient data. The utility of SD is actively scrutinized in health care research, but the role of sample size for actionability of SD is insufficiently explored.
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- Diagnosing rare cancers is tough and often takes a long time, according to a study that examined the experiences of 1541 patients in The Netherlands from GP visits to final diagnoses.
- Most patients (76.0%) started with a GP consultation, and while 76.3% were referred to a hospital within three months, 32.1% received incorrect diagnoses that led to unnecessary treatments.
- The study found significant differences in diagnosis timelines between solid and non-solid tumors, with patients experiencing varying waits; improving research on symptoms and clinical networks could help reduce these delays.
Article Synopsis
- The study aims to assess the global cancer burden in adolescents and young adults (ages 15-39) for the years 2022 and 2050, focusing on incidence, mortality, and case fatality.
- About 1.3 million new cancer cases and approximately 377,600 cancer-related deaths were reported in this age group in 2022, with higher incidence and mortality rates in females compared to males.
- The research indicates that while high-income countries have the highest cancer incidence, low-income countries face higher death rates, leading to significantly differing case fatality rates between these regions.