Exploring the antidiabetic effect of various therapeutic essential oils synergistically with repaglinide.

Objective: This study aimed to evaluate the antidiabetic efficacy of microemulsions formulated with cardamom oil, black seed oil, and olive oil. The goal was to determine the optimal formulation for stable microemulsions and assess their potential as innovative drug delivery systems for the antidiabetic drug repaglinide.

Methods: Initial phase diagrams were constructed to identify the optimal ratios of oil, water, surfactant (Tween 80), and cosurfactant (ethanol) for producing stable microemulsions.

Cytogenetic impact of gamma radiation and its effects on growth, yield and drought tolerance of maize (Zea mays L.).

Maize is the third most important grain crop worldwide after wheat and rice; it is a vital global crop, serving as a key source of food, animal feed, and industrial products, making it essential for food security and economic stability in many countries. Drought stress adversely affects water uptake and can stunt growth, reducing the overall productivity of maize. So, this study was carried out to investigate the cytogenetic effects of gamma radiation and drought stress on maize SC131 genotype, focusing on chromosomal aberrations in seedling root meristems induced by varying doses of gamma irradiation (50, 100, 150, 200, and 250 Gray) and drought stress imposed by 10% polyethylene glycol (PEG).

Recent developments and future directions in point-of-care next-generation CRISPR-based rapid diagnosis.

The demand for sensitive, rapid, and affordable diagnostic techniques has surged, particularly following the COVID-19 pandemic, driving the development of CRISPR-based diagnostic tools that utilize Cas effector proteins (such as Cas9, Cas12, and Cas13) as viable alternatives to traditional nucleic acid-based detection methods. These CRISPR systems, often integrated with biosensing and amplification technologies, provide precise, rapid, and portable diagnostics, making on-site testing without the need for extensive infrastructure feasible, especially in underserved or rural areas. In contrast, traditional diagnostic methods, while still essential, are often limited by the need for costly equipment and skilled operators, restricting their accessibility.

The Association Between Janus Kinase 2 and Factor V Leiden Mutations and Thrombotic Complications in Patients With Myeloproliferative Disorders: A Study From Saudi Arabia.

Background The Janus kinase 2 (JAK2) V617F mutations are related to increased thrombotic risk in patients with myeloproliferative disorders (MPDs). However, little is known about whether inherited thrombophilia represents an additive risk factor in mutated subjects. We addressed the association between combined mutations of JAK2 and factor V Leiden (FVL) and thrombotic complications in Saudi Arabian patients with MPDs.

The bacterial microbiome and cancer: development, diagnosis, treatment, and future directions.

The term "microbiome" refers to the collection of bacterial species that reside in the human body's tissues. Sometimes, it is used to refer to all microbial entities (bacteria, viruses, fungi, and others) which colonize the human body. It is now generally acknowledged that the microbiome plays a critical role in the host's physiological processes and general well-being.