Publications by authors named "W M Lester"
Demystifying autoimmune HIT: what it is, when to test, and how to treat.
Hematology Am Soc Hematol Educ Program
December 2024
Article Synopsis
- Antibodies to platelet factor 4 (PF4) are mainly associated with classical heparin-induced thrombocytopenia (cHIT), while a new condition called vaccine-induced thrombocytopenia and thrombosis (VITT) has emerged related to COVID-19 vaccines.
- Differentiation between heparin-dependent and heparin-independent anti-PF4 conditions has led to the development of a rapid anti-PF4 assay that is not affected by heparin.
- VITT-like disorders, which present independently of heparin and are often triggered by infections or certain surgeries, are rare but associated with high mortality and require specific treatment approaches like immunomodulation therapy.
Introduction: Valoctocogene roxaparvovec is an adeno-associated virus vector serotype 5 (AAV5)-mediated gene therapy approved for severe haemophilia A (HA).
Aim: To report the safety and efficacy of valoctocogene roxaparvovec 7 years after dosing in a phase 1/2 clinical study (NCT02576795).
Methods: Males ≥18 years with severe HA (factor VIII [FVIII] ≤1 international unit [IU]/dL) who were previously receiving exogenous FVIII and had no history of FVIII inhibitors or anti-AAV5 antibodies received valoctocogene roxaparvovec treatment and were followed for 7 (6 × 10 vg/kg; n = 7) and 6 (4 × 10 vg/kg; n = 6) years.
ANNA's Administration SPN created this proposal as a clinical practice project to re-evaluate how training and education are provided to individuals working in the dialysis setting. This article describes an education initiative based on the escape room methodology to provide a fresh approach on dialysis curriculum.
View Article and Find Full Text PDFThere has been much written about work-life balance, both in nursing and other professions. Additionally, the term has taken on multiple definitions over the years, and it is often touted as central to an organization's mission. The defines work-life balance quite simply as "the amount of time you spend doing your job compared with the amount of time you spend with your family and doing things you enjoy.
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