Publications by authors named "W M Huisman"
Background: SARS-CoV-2 has been associated with a higher proportion of asymptomatic infections and lower mortality in sub-Saharan Africa than high-income countries. However, there is currently a lack of data on cellular immune responses to SARS-CoV-2 in people living in Africa compared with people in high-income regions of the world. We aimed to assess geographical variation in peripheral and mucosal immune responses.
View Article and Find Full Text PDFLifestyle score is associated with cellular immune profiles in healthy Tanzanian adults.
Brain Behav Immun Health
November 2024
Article Synopsis
- The immune system and vaccine responses differ globally, influenced by geographical, economic, and lifestyle factors, particularly between rural and urban populations.
- A study in Tanzania assessed the immune profiles of 100 healthy individuals, correlating their immune cell types with a lifestyle score derived from living conditions and diet.
- Findings revealed that rural individuals with low lifestyle scores had more activated immune cells, while urban individuals with higher scores had a less activated immune response, suggesting these profiles may affect vaccine responses and relate to lower rates of autoimmunity and allergies in low- and middle-income settings.
Cytomegalovirus (CMV) is one of the most common and relevant opportunistic pathogens in people who are immunocompromised, such as kidney transplant recipients (KTRs). The exact mechanisms underlying the disability of cytotoxic T cells to provide sufficient protection against CMV in people who are immunosuppressed have not been identified yet. Here, we performed in-depth metabolic profiling of CMV-specific CD8+ T cells in patients who are immunocompromised and show the development of metabolic dysregulation at the transcriptional, protein, and functional level of CMV-specific CD8+ T cells in KTRs with noncontrolled CMV infection.
View Article and Find Full Text PDFArticle Synopsis
- Medical laboratories must document various activities to maintain service quality, leading to the generation of multiple documents, forms, and reports.
- Each document's retention time must be specified, adhering to national laws or professional guidelines, with a defined retention schedule created when guidelines are lacking.
- The EFLM Working Group offers recommendations for retention periods based on a risk-based approach (FMEA), aligning with ISO 15189:2022 for general quality management.