The past, present, and future of exudative age-related macular degeneration treatment.

Treatment of exudative age-related macular degeneration has been revolutionized within the last 6 years with the introduction of vascular endothelial growth factor neutralizing agents. Previously popular "destructive treatments," such as laser photocoagulation and photodynamic treatment have either been abandoned or used as an adjunct to pharmacotherapy. Despite the increase in vision after antivascular endothelial growth factor (VEGF) agents, they require repetitive and costly intravitreal injections that also carry the inherit risks of infection, retinal tears, and detachment.

Immunohistochemical detection of carcinoembryonic antigen in esophageal carcinomas: a comparison with other gastrointestinal neoplasms.

Background: Although the prognostic value of Carcinoembryonic antigen (CEA) in colorectal cancer follow-up is well known, CEA expression in esophageal cancer is not widely recognized and studies correlating tissue CEA expression in stomach cancers with tumor differentiation have yielded contradictory results. We compared the CEA expression in esophageal, gastric and colorectal carcinomas in order to elucidate its diagnostic and prognostic significance and to evaluate the potential role of tissue CEA localization for the clinical evaluation of esophageal carcinomas.

Materials And Methods: CEA expression in 84 biopsies of carcinomas of the gastrointestinal tract (38 colorectal, 22 gastric, 24 esophageal) was evaluated by immunohistochemistry.

Umbilical arterial S-nitrosothiols in stressed newborns: role in perinatal circulatory transition.

S-Nitrosothiols are potent endogenous vasodilators recently found to be in greater concentrations in fetal umbilical venous than arterial blood. We hypothesized that neonatal increases in SNOs may be involved in the normal human perinatal circulatory transition. Paired human umbilical artery and vein plasma samples were collected after birth.

Pregnancy outcome in military and civilian women.

Physical and medical risk factors have long been linked to prematurity and intrauterine growth retardation. Recently, out-of-home employment has been cited as an additional risk. The primary objective of this investigation was to compare pregnancy risks and birth outcome in two groups of employed women (one military and one civilian).