Obesity is Independently Associated with Increased Risk of Fecal Incontinence and Altered Rectal Sensitivity.

Background: Hindgut symptoms are poorly understood complications of obesity. The impact of obesity on fecal incontinence (FI) and anorectal physiology remains unclear, with inconsistent results in prior studies. We aimed to evaluate the relationship between obesity and FI, and the physiological changes in anorectal function.

Suppressing Polaronic Defect-Photocarrier Interaction in Halide Perovskites by Pre-distorting Its Lattice.

In halide perovskites, photocarriers can have strong polaronic interactions with point defects. For iodide-deficient MAPbI, we found that the Fermi level can shift significantly by 0.6-0.

A Robust and Sensitive New Peak Detection and Identification Method for Mass Spectrometry-Based Differential Analysis in Biologics Characterization.

New peak detection (NPD) is a significant component of the multiattribute method (MAM) for MS use to facilitate the detection of quality attributes exhibiting abnormal ratio changes, vanishing attributes, or newly emerging attributes. However, challenges remain to get a balanced sensitivity and minimize false positives in NPD. In this study, we have developed a robust NPD and identification method to enhance sensitivity 10-fold (0.

Precise template-free correction restores gene function in Tay-Sachs disease while reframing is ineffective.

Tay-Sachs disease is a fatal neurodegenerative disorder caused by mutations inactivating the metabolic enzyme HexA. The most common mutation is c.1278insTATC, a tandem 4-bp duplication disrupting expression by frameshift.