Publications by authors named "W M Awad"
Article Synopsis
- The national early warning score (NEWS) aims to enhance the detection and assessment of severe acute illnesses in NHS patients, specifically evaluating its effectiveness for cardiac surgery patients.
- A study of 3710 adult cardiac surgery patients assessed how well a NEWS trigger score of 5 predicted patient deterioration and outcomes after surgery, finding that 4.4% of patients prompted Critical Care Outreach Team (CCOT) calls.
- Results showed higher in-hospital mortality rates for patients referred to the CCOT (10.5%) compared to those not referred (3.9%), indicating a need for tailored scoring systems for better patient outcomes in cardiac care.
MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells.
Proc Natl Acad Sci U S A
December 2024
The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal-associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1-restricted T cells expressing more diverse T cell receptors (TCRs), some with anti-tumor reactivity. However, knowledge of the range of the antigen(s) that can activate diverse MR1-reactive T cells remains incomplete.
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- Patients with breast cancer often face serious adverse events (AEs) during treatment, particularly while receiving antineoplastic therapy in outpatient settings.
- A study involving 1168 patients found that 40% experienced at least one serious AE, leading to emergency department visits or treatment adjustments.
- The most common AEs observed were musculoskeletal and gastrointestinal issues, and taxane-based treatments were linked to the highest incidence of AEs, highlighting a need for strategies to minimize these complications in future research.
Objectives: To evaluate the effect of procalcitonin-guided management on the duration of antibiotic therapy in critically ill cancer patients with sepsis.
Design: Randomized, controlled, single-blinded trial.
Setting: A comprehensive multidisciplinary cancer hospital in Jordan.
Article Synopsis
- Heart failure is increasingly challenging due to an ageing population, but mechanical circulatory support devices like ventricular assist devices and Extracorporeal Membrane Oxygenation (ECMO) are evolving to help manage this condition.
- This review highlights how these devices function to relieve pressure on the heart and improve physiological measures such as stroke volume and intracardiac pressure, which begin to change immediately after device implantation.
- While devices like Impella and TandemHeart have shown positive effects on heart function in patients with cardiogenic shock, more research is needed to evaluate their long-term clinical outcomes, and choosing the right device depends on individual patient circumstances.