Development of a core outcome set for interventions to prevent stillbirth.

Aims: To develop a core outcome set for trials investigating interventions to prevent stillbirth.

Materials & Methods: Outcomes identified from a systematic literature review and semi-structured interviews with parents in Australia and the UK were entered into a two-round online Delphi survey and focus group/consensus meetings.

Results: A core outcome set containing 11 outcomes in two categories.

Developing a core outcome set in interventions to prevent stillbirth: A systematic review on variations of outcome reporting.

Objective: To determine which outcomes have been previously reported in previous stillbirth prevention studies.

Research Design: Systematic review of reviews: We searched the Cochrane Database of Systematic Reviews, EMBASE and Pubmed for systematic reviews and meta- analyses investigating interventions to prevent stillbirth and its major risk factors.

Data Collection And Analysis: Two reviewers identified and extracted outcomes independently.

Application of the charge regulation model to transport of ions through hydrophilic membranes: one-dimensional transport model for narrow pores (nanofiltration).

The charge regulation concept is combined with the Navier-Stokes and Nernst-Planck equations to describe the ion retention of nanofiltration membranes consisting of narrow cylindrical pores. The charge regulation approach replaces the assumption of a constant charge or a constant potential at the membrane pore surface, and accounts for the influence of pH, salt concentration, and type of electrolyte on ion retention. In the current model, radial concentration and potential gradients are considered to be negligibly small (valid for narrow enough pores), resulting in a one-dimensional transport description.

Drug resistance in epilepsy: human epilepsy.

The basis of drug resistance in human epilepsy is not understood. Parallels with resistance in cancer suggest that drug resistance proteins may have a role. To examine this possibility, we have studied human brain tissue containing pathologies capable of causing refractory epilepsy.

Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library.

The primary sequence of a cDNA encoding a novel transglutaminase from a human prostate cDNA library is reported. The sequence is compared to other known transglutaminases in a multiple alignment. The deduced peptide sequence is 51% identical to a rat prostate transglutaminase.