Publications by authors named "W Limin"
Background: Benralizumab is indicated as add-on therapy in patients with uncontrolled, severe eosinophilic asthma; it has not yet been evaluated in a large Asian population with asthma in a clinical trial.
Objective: To evaluate the efficacy and safety of benralizumab in patients with severe asthma in Asia.
Methods: MIRACLE (NCT03186209) was a randomized, Phase 3 study in China, South Korea, and the Philippines.
Aim: To explore whether nanoparticles (NPs) can be transported into the CNS via the taste nerve pathway.
Materials & Methods: ZnO and TiO NPs were tongue-instilled to male Wistar rats. Toxicity was assessed by Zn/Ti biodistribution, histopathological examination, oxidative stress assay, quantitative reverse-transcriptase PCR analysis, learning and memory capabilities.
Article Synopsis
- This study investigates the harmful effects of prenatal exposure to zinc oxide (ZnO) nanoparticles on the brain development of rat offspring.
- Pregnant rats were given ZnO nanoparticles, and various toxicity assessments were conducted, including brain zinc levels and memory tests for the offspring.
- The results showed increased zinc in the offspring's brains, abnormal neuron structures, signs of cell death, and impaired learning and memory in adulthood, especially in female rats.
Given the wide application of zinc oxide nanoparticles (ZnO NPs), the health hazards of these particles have attracted extensive worldwide attention. Many more studies on the biological interactions of ZnO NPs have been performed in recent years. In this study, we focused on the biological effects on BV2 microglial cells induced by ZnO NPs at non- or sub-toxic concentrations.
View Article and Find Full Text PDFObjective: We examined the prevalence of and characteristics associated with drink-driving in China. We compared this study's drink-driving findings with those from the United States to explore how effective traffic safety interventions from Western cultures might be adapted for use in China.
Methods: Data from the 2010 China Chronic Disease and Risk Factor Survey were analyzed to describe the prevalence and characteristics associated with drink-driving in China.