Publications by authors named "W Lawrence Drew"
Prediction of stroke severity: systematic evaluation of lesion representations.
Ann Clin Transl Neurol
December 2024
Article Synopsis
- The study aimed to identify which imaging features can best predict poststroke deficits by analyzing data from three different patient groups who experienced acute strokes.
- It was found that models trained on small datasets performed well within their own dataset but failed to generalize to new patient data; however, using larger and multicenter datasets significantly improved predictive performance.
- Including structural and functional disconnection in the models yielded better predictions of stroke severity compared to relying solely on lesion volume or location.
Importance: Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well as emerging data from responsive neurostimulation trials, suggest conceptualizing TLE as a network disorder.
Objective: To assess whether brain networks connected to areas of atrophy in the hippocampus align with the topography of distant neuroimaging alterations and RNS response.
Article Synopsis
- * The research compared brain lesions causing parkinsonism with those causing seizures using advanced brain network mapping techniques.
- * Findings indicate that lesions related to parkinsonism and seizures are associated with distinct, opposite brain networks, particularly highlighting the role of the substantia nigra in this relationship.
Objective: Anxiety disorders and subsyndromal anxiety symptoms are highly prevalent in late life. Recent studies support that anxiety may be a neuropsychiatric symptom during preclinical Alzheimer's disease (AD) and that higher anxiety is associated with more rapid cognitive decline and progression to cognitive impairment. However, the associations of specific anxiety symptoms with AD pathologies and with co-occurring subjective and objective cognitive changes have not yet been established.
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- Recent studies suggest a link between parkinsonism and seizures, but it's unclear which causes which.
- Researchers analyzed brain lesions in patients with parkinsonism and those with seizures to understand their connection to brain networks.
- They found that lesions associated with parkinsonism and seizures mapped to opposite brain networks, highlighting a distinct neuroanatomical relationship that clarifies previous conflicting findings.