Publications by authors named "W L Shaw"
The muscle synergy concept suggests that the human motor system is organized into functional modules composed of muscles "" toward common task goals. This study offers a nuanced computational perspective to muscle synergies, where muscles interacting across multiple scales have functionally similar, complementary, and independent roles. Making this viewpoint implicit to a methodological approach applying Partial Information Decomposition to large-scale muscle activations, we unveiled nested networks of functionally diverse inter- and intramuscular interactions with distinct functional consequences on task performance.
View Article and Find Full Text PDFLipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we show that impairing lipolysis in Anopheles gambiae, the major malaria vector, leads to embryonic lethality.
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- The study investigates how surviving malaria parasites interact with mosquito midgut cells to form oocysts, which are crucial for producing infectious sporozoites.
- Using single-cell RNA sequencing, researchers explored developmental transitions and mosquito-parasite interactions over time and different metabolic conditions.
- Key findings include the essential role of a transcription factor called SIP2 for infecting human liver cells, and the discovery of mechanisms that help parasites adhere to the midgut without causing damage, providing potential targets for stopping malaria transmission.
A molecular view of peptoid-induced acceleration of calcite growth.
Proc Natl Acad Sci U S A
November 2024
The extensive deposits of calcium carbonate (CaCO) generated by marine organisms constitute the largest and oldest carbon dioxide (CO) reservoir. These organisms utilize macromolecules like peptides and proteins to facilitate the nucleation and growth of carbonate minerals, serving as an effective method for CO sequestration. However, the precise mechanisms behind this process remain elusive.
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- Pancreatic heterotopia (PH) refers to the presence of pancreatic tissue in locations outside its normal site, usually without any connection to the pancreas, and is typically asymptomatic.
- Symptoms, when they occur, can resemble those of Crohn's disease, including abdominal pain, nausea, and diarrhea, and often manifest in adulthood.
- A case study revealed a patient initially diagnosed with Crohn's disease, who later had surgery that identified ectopic pancreatic tissue as the underlying cause of her gastrointestinal symptoms, which resolved after resection.