Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation.

Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies.

Cell size in the lateral geniculate nucleus of cats reared with esotropia and sagittal transection of the optic chiasm.

We have attempted to investigate the role of extraretinal influences in controlling visual system development by rearing cats with esotropia in combination with sagittal transection of the optic chiasm. This combination leave two intact A1 laminae, one innervated by the deviated eye and one innervated by the unoperated eye and thus minimizes the contributions of retinally mediated influences. Cell size measurements in the dorsal lateral geniculate nucleus revealed that the neurons in the A1 lamina innervated by the deviated eye were, on average, 10-15% smaller than their counterparts in the contralateral A1 lamina.

Rearing cats with eyelid suture has both early and late effects on cells in the lateral geniculate nucleus.

We have assessed the effects of duration of infant-onset deprivation, and therefore the age of the subject at the time of data collection, on the physiology and morphology of cells in the lateral geniculate nucleus (LGN) of cats. Twenty-two kittens underwent lid suture. Electrophysiological experiments were performed in 12 of these subjects when they were between 5 and 16 months of age.

6-Hydroxydopamine treatment blocks the effects of chronic monocular paralysis in the cat's lateral geniculate nucleus.

The abnormal patterns of binocular stimulation produced by unilateral eye immobilization (monocular paralysis) alter the physiology of the lateral geniculate nucleus (LGN), shifting the LGN X/Y ratio in such a way that X cells are encountered far less frequently than Y cells. These changes are not observed in cats treated with intraventricular injections of the neurotoxin, 6-hydroxydopamine (6-OHDA) during the period of chronic monocular paralysis. Additional experiments indicated that the blockade was not due to any non-specific effects associated with the injection procedures, nor to any direct effects the drug itself may have had on LGN cell recording.

The influence of anesthesia upon binocular processes controlling the recordability of X- and Y-cells in the lateral geniculate nucleus of the cat.

The interaction between anesthesia and binocular physiology was explored using chronic monocular paralysis. Monocular paralysis allows analysis and classification of lateral geniculate nucleus (LGN) cells without systemic paralysis and anesthesia and also produces a tonic bias in binocular mechanisms which control the relative recordability of X- and Y-cells (i.e.