In vivo reversal of depolarizing neuromuscular blockade.

The antagonism of depolarizing blockers, principally succinylcholine and decamethonium, by tetraethyl- and tetrabutylammonium ions in an in vivo neuromuscular preparation in anesthetized cats is described; possible mechanisms for these effects are discussed. Tetraethyl- (50-100 mg/kg, i.v.

Cholinergic and anticholinergic drug effects on survival during hypoxia: significant gender differences.

We examined central and peripheral components of cholinergic drug protection against hypoxia in male and female mice. Survival times were measured in groups of control and treated (i.p.

Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs.

The neonatal pharmacology of neuromuscular drugs was studied in vivo in newborn rats and in vitro in neonatal phrenic nerve-hemidiaphragm preparations. Drugs used to probe neuromuscular development in rat neonates were physostigmine, edrophonium, neostigmine, 4-aminopyridine, d-tubocurarine (dTc), and succinylcholine. The prejunctional actions of these drugs were monitored in relation to neonatal age by the appearance of stimulus-evoked repetitive discharge initiated by motor nerve endings and the occurrence and magnitude of the resulting enhancement of twitch tension.

Some new observations on caffeine-induced rhythmic hyperpolarization in frog sympathetic ganglion cells.

Unstimulated bullfrog sympathetic ganglia were studied in vitro by intracellular and extracellular recording methods. In 80% of the cells impaled with K citrate microelectrodes, caffeine caused initial hyperpolarization (ICH) followed by rhythmic membrane hyperpolarization (RMH). Four different patterns of rhythmicity were observed, the most common being a regular beating pattern.