Outcomes of Endoscopic versus Microscopic Ossicular Chain Reconstruction-A Systematic Review and Meta-analysis.

Objective: The efficacy of the transcanal endoscopic approach in tympanoplasty, cholesteatoma removal, and stapedotomy is detailed. This study reviews evidence on the feasibility of endoscopic ossiculoplasty as a suitable alternative to traditional microscopic ossiculoplasty.

Data Sources: PubMed, Embase, and Cochrane Library were searched from inception to 19 June 2024 for articles comparing endoscopic and microscopic ossicular chain reconstruction.

Interactions between cellulose nanocrystals and conventional/gemini surfactants.

Research on the interaction between surfactants and cellulose nanocrystals (CNC) has mainly focused on the interaction between CNC and conventional surfactants, and there are no reported studies on the interaction between CNC and gemini surfactants. The interactions between CNC and conventional surfactant (tetradecyltrimethylammonium bromide, termed as TTAB), asymmetric gemini surfactant ([CH(CH)N(CH)N(CH)CH]Br (14-6-6)) or symmetric gemini surfactant ([CH(CH)N(CH)N(CH)CH]Br (14-6-14)) were examined. With increasing surfactant concentration, interaction of TTAB/CNC was described by three regions, i.

Overview of diabetes agents in cardiovascular disease: it takes an orchestra to play Tchaikovsky in symphony.

Purpose Of Review: The aim of this review was to discuss the use and concerns of diabetes agents, clinical targets, and key aspects to be considered in the management of patients with type 2 diabetes mellitus (T2DM), and at high risk or established cardiovascular disease (CVD).

Recent Findings: The recent European and American guidelines recommended SGLT2 inhibitors and GLP-1 receptor agonists as the preferred first-line diabetes agents in patients with T2DM and CVD. This is a paradigm shift from using metformin as first-line therapy.