Extraabdominal desmoid tumor.

An extraabdominal desmoid tumor of the shoulder occurring in a middle-aged woman without Gardner's syndrome is described. Two punch biopsy specimens from the tumor were initially interpreted as representing scar tissue; a third incisional biopsy specimen demonstrated the characteristic features of a desmoid tumor. Because desmoid tumors are locally aggressive, early diagnosis and treatment are crucial to minimize morbidity and mortality.

Melanocytic activation in HIV-1 disease: HMB-45 staining in common acquired nevi. Military Medical Consortium for the Advancement of Retroviral Research.

Background: An increase in pigmented lesions has been reported in HIV-1-infected patients. In a study of HIV-1-positive patients, we have seen patients who noticed new or changing pigmented lesions.

Objective: The goal of this study was to determine to what degree these pigmented lesions showed evidence of significant melanocytic proliferation as opposed to increased pigment production without significant melanocytic proliferation.

Androgen biology as a basis for the diagnosis and treatment of androgenic disorders in women. II.

In the May 1993 issue of the Journal we reviewed the basic science of androgen biology in women. We now discuss the evaluation of suspected hyperandrogenism and the therapeutic modalities available.