Publications by authors named "W Kutschke"
Background: Decreased peak sodium current (I) and increased late sodium current (I), through the cardiac sodium channel Na1.5 encoded by SCN5A, cause arrhythmias. Many Na1.
View Article and Find Full Text PDFType 2 diabetes and obesity are associated with increased risk of cardiovascular disease, including heart failure. A hallmark of these dysmetabolic states is hyperinsulinemia and decreased cardiac reserve. However, the direct effects of hyperinsulinemia on myocardial function are incompletely understood.
View Article and Find Full Text PDFFunctional resilience of C57BL/6J mouse heart to dietary fat overload.
Am J Physiol Heart Circ Physiol
November 2021
Molecular mechanisms underlying cardiac dysfunction and subsequent heart failure in diabetic cardiomyopathy are incompletely understood. Initially we intended to test the role of G protein-coupled receptor kinase 2 (GRK2), a potential mediator of cardiac dysfunction in diabetic cardiomyopathy, but found that control animals on HFD did not develop cardiomyopathy. Cardiac function was preserved in both wild-type and knockout animals fed high-fat diet as indicated by preserved left ventricular ejection fraction (LVEF) although heart mass was increased.
View Article and Find Full Text PDFArticle Synopsis
- Both glucose and lactate are crucial for heart metabolism, especially under stress, as they get converted to pyruvate for energy production in mitochondria.
- The study found that mice lacking a key protein for pyruvate transport (MPC1) developed severe heart issues, leading to pathological changes and early death.
- A ketogenic or high-fat diet helped reverse damage in these mice by providing alternative energy sources, but only a preemptive diet was effective in saving them from rapid heart failure after an induced stress condition.