Publications by authors named "W Krzysciak"
Identifying disease predictors through advanced statistical models enables the discovery of treatment targets for schizophrenia. In this study, a multifaceted clinical and laboratory analysis was conducted, incorporating magnetic resonance spectroscopy with immunology markers, psychiatric scores, and biochemical data, on a cohort of 45 patients diagnosed with schizophrenia and 51 healthy controls. The aim was to delineate predictive markers for diagnosing schizophrenia.
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- The study emphasizes the need for a personalized approach to schizophrenia due to its polygenic nature, seeking laboratory biomarkers from various sources including blood, brain imaging, and patient self-reports.
- Metabolomics research involving serum samples from patients and healthy volunteers identified three key biochemical indicators—cortisol, glutamate, and lactate—that correlate with clinical assessments and imaging results.
- The findings show significant relationships between blood lactate levels and clinical/neuroimaging parameters, suggesting that changes in lactate and cortisol levels may reflect underlying immunological shifts and brain chemistry relevant to schizophrenia subtypes.
The lactoperoxidase (LPO) system shows promise in the prevention of dental caries, a common chronic disease. This system has antimicrobial properties and is part of the non-specific antimicrobial immune system. Understanding the efficacy of the LPO system in the fight against biofilms could provide information on alternative strategies for the prevention and treatment of caries.
View Article and Find Full Text PDFSchizophrenia is characterized by complex metabolic dysregulations and their consequences. Until now, numerous theories have explained its pathogenesis, using a spectrum of available technologies. We focused our interest on lipid profile-periphery high-density cholesterol level and lipoproteins in the human brain and compared magnetic resonance imaging (MRI) scans of patients with schizophrenia and the healthy group.
View Article and Find Full Text PDFObjectives: Assessment of the association between weight gain in patients with first-episode psychosis (FEP) and biopsychosocial and sociological factors.
Methods: 25 subjects with FEP aged 14-35 examined in week 1 (P1) and after three months of hospitalization (P3) were enrolled in the study. Within 3 months all patients were diagnosed with schizophrenia.