The in vivo effects of beta-3-receptor agonist CGP-12177 on thyroxine deiodination in cold-exposed, sympathectomized rat brown fat.

Objective: The effects of the beta-3-receptor agonist CGP-12177 on thyroxine (T4) deiodination in sympathectomized (SX) interscapular brown adipose tissue (BAT) were assessed in 300 g body weight (BW) Wistar rats.

Design: Seven days after SX, groups of rats were implanted s.c.

["Non-solvent shock agglomeration"--the technology of a new alternative method for determination of ibuprofen. 6. Stability of s(+)-ibuprofen].

Due to its low melting range approx. 53 degrees C optically pure ibuprofen can be regarded as problematic in a pharmaceutic-technological sense. With regard to the non-solvent shock agglomeration method this means that the process and product temperatures must strictly be kept in the range of 10 K above the melting point of the substance.

["Non-solvent shock agglomeration"--technology of a new alternative method for sustained release of ibuprofen. 5. Production and evaluation of retard formulations].

Conventional and prepared racemic and optically pure substances were assessed with regard to their suitability to be processed into retarded formulations by direct tabletting. In this respect conventional ibuprofen and specially granulated substances usually show only insufficient properties. Fluid bed granulated S(+)ibuprofen, however, can be suitably transformed into slow release forms by using traditional agents (above all cellulose ether); the low bulk and tapped volume of these granulates, however, is a limiting factor.

["Non-solvent shock agglomeration technology" as a new alternative method for work on ibuprofen. 4. Production and evaluation of quick release forms].

During compaction of shock-agglomerated S(+)ibuprofen it was of interest if and how far the sometimes strongly differing quality or the origin of the source material has effects on the tabletting properties and on tablet quality. Moreover, conventional and shock agglomerated substances are compared with regard to the parameters mentioned. The technology of "non-solvent shock agglomeration" results in substances suitable for direct tabletting.

A possible role for acetylcholine in the dialogue between thymocytes and thymic stroma.

In this article we will review data suggesting that acetylcholine takes part in the mutual interplay between developing T cells and thymic epithelium, and thereby may influence the generation of the T-cell repertoire. In the first part we will recapitulate our findings according to which cholinergic agonists affect thymocyte apoptosis via a nicotinergic effect on thymic epithelial cells. In the second part we will present evidence that acetylcholine within the thymus is mainly derived from the thymocytes themselves, and that the production and release of this neurotransmitter is dependent on activation of thymic lymphocytes.