Publications by authors named "W Klepetko"
Background: Pleural mesothelioma (PM) is a cancer with usually a dismal prognosis. However, long-term survivors do exist. Herein, we analyzed long-term survivors (>5 years after surgery) from high-volume centres around the world.
View Article and Find Full Text PDFObjectives: Surgical treatment for airway stenosis necessitates personalized techniques based on the stenosis location and length, leading to favourable surgical outcomes. However, there is limited literature on functional outcomes following laryngotracheal surgery with an adequate number of patients.
Methods: We conducted a retrospective analysis of patients who underwent laryngotracheal surgery at the Department of Thoracic Surgery, Medical University of Vienna, from January 2017 to June 2021.
Chronic thromboembolic pulmonary hypertension (CTEPH) is successfully treatable with pulmonary endarterectomy (PEA), balloon pulmonary angioplasty, and medical therapy. Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management risk score (RRS) is able to predict long-term outcome in inoperable patients or in patients with residual PH after surgery. We performed a post hoc analysis of RRS in patients who were enrolled in the CTREPH study (NCT01416636), a randomized, double-blind clinical trial comparing high-dose and low-dose subcutaneous (SC) treprostinil in patients with severe CTEPH that was classified by an interdisciplinary CTEPH team as nonoperable, or as persistent or recurrent pulmonary hypertension after PEA.
View Article and Find Full Text PDFArticle Synopsis
- Lung transplantation experiences antibody-mediated rejection (AMR) less frequently than other organs, and previous research did not identify molecular AMR in lung biopsies.
- New findings indicate that AMR in kidney transplants can occur without donor-specific antibodies (DSA), linked to natural killer (NK) cell activity, prompting researchers to investigate a similar scenario in lung biopsies.
- The study identified a molecular rejection-like state (NKRL) in lung transplants characterized by increased NK cell transcripts, differentiating it from traditional T cell-mediated rejection, while highlighting that NKRL often goes unrecognized clinically and doesn't correlate with negative outcomes like chronic lung dysfunction.
Even in specialised centres, surgical procedures on the airway are only rarely performed in paediatric patients. Moreover, knowledge of various specific anatomical characteristics, diseases and surgical techniques is a prerequisite to treat these patients. Most commonly, sequelae of long-term intubation or tracheostomy in multimorbid patients necessitate surgical repair.
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