Stability of an epidural analgesic solution containing adrenaline, bupivacaine and fentanyl.

Background: A low dose solution of adrenaline 2 microg x ml(-1), fentanyl 2 microg x ml(-1) and bupivacaine 1 mg x ml(-1) has been reported to give superior pain control when used for epidural analgesia after major surgery. The present paper describes the compounding and chemical stability of this triple-component solution during storage and use.

Methods: Sterile triple-component concentrates (11X) were diluted by the use of gas isolator technology to give ready-to-use infusion solutions.

Photodestabilization of epinephrine by sodium metabisulfite.

The effect of light and bisulfite on infusion solutions containing epinephrine (2 micrograms/mL), bupivacaine hydrochloride (1 mg/mL), fentanyl (2 micrograms/mL) and sodium edetate (0.18 microgram/mL) was investigated. Solutions were made isotonic using sodium chloride, and they contained either 1.

A new injectable carbamazepine solution--antiepileptic effects and pharmaceutical properties.

Carbamazepine (CBZ) could be dissolved in Glycofurol (polyethylene glycol monotetra-hydrofurfuryl ether) with concentrations up to 100 mg/ml, and the solutions were stable for at least 14 days. Ethanol or benzyl alcohol was added without loss in solubility, while water, human serum albumin or Intralipid always led to immediate precipitation. The effect of a CBZ/Glycofurol solution on focal seizure threshold in the visual cortex in cats was investigated using a cerveau isolé preparation.