Inhibition of amyloid beta oligomer accumulation by NU-9: A unifying mechanism for the treatment of neurodegenerative diseases.

Protein aggregation is a hallmark of neurodegenerative diseases, which connects these neuropathologies by a common phenotype. Various proteins and peptides form aggregates that are poorly degraded, and their ensuing pathological accumulation underlies these neurodegenerative diseases. Similarities may exist in the mechanisms responsible for the buildup of these aggregates.

Postmortem diagnostics in sudden unexpected death in infants and children: use and utility.

Unlabelled: Sudden unexpected death in infants (SUDI) and children (SUDC) requires thorough investigation to identify causes and prevention strategies. In the Netherlands, these deaths are investigated using the standardized postmortem evaluation of sudden unexpected death in infants and children (PESUDIC) procedure. This study examines the use of various diagnostic tests within PESUDIC and their effectiveness in determining causes of death.

Avian air sacs and neopulmo: their evolution, form and function.

The avian respiratory system is composed of an exchange structure (parabronchi) and a pump (air sacs) to perform gas exchange. While there are many studies dealing with the morphology and function of the palaeopulmonic parabronchi, the air sacs and the neopulmo have been somewhat neglected from a comparative and functional point of view, not always receiving a closer examination that they deserve. While a decent amount of data are available regarding air sac and neopulmo morphology on a family level or for domestic species, several orders of birds have yet to be investigated.

Public Health Communication Approaches for Building Common Ground.

Changes in the information landscape and increasing polarization in society over recent decades have made it more difficult to establish common ground, which poses a profound challenge to effective health communication and public health in general. We highlight the importance of assessing health communication approaches for their potential to bring people together and reduce polarization. We outline several communication approaches that use existing common ground (e.

Development and maintenance of consensus recommendations on pediatric outpatient antibiotic therapy in Germany: a framework for rational use.

Unlabelled: In pediatric outpatient care, overuse and misuse of antibiotics is linked to a high risk of adverse events and increased antibiotic resistance. In 2019, building upon the work of the Antibiotic Therapy in Bielefeld (AnTiB) project (founded in 2016), a collaboration among the AnTiB, the German Society for Pediatric Infectious Diseases (DGPI), and the Professional Association of Outpatient Pediatricians and Adolescent Physicians (BVKJ) was established to develop consensus recommendations for antibiotic therapy in pediatric outpatient settings in Germany. This working group became the Antibiotic Stewardship in Outpatient Pediatrics (ABSaP).