Publications by authors named "W Khemissi"
Article Synopsis
- A study was conducted to investigate the protective effects of phycocyanin, an extract from blue algae, against male infertility caused by alcohol consumption.
- Male rats were used in the experiment, where some were exposed to ethanol to induce oxidative stress, while others received phycocyanin treatment or both.
- Results indicated that phycocyanin effectively prevented harmful effects on sperm production and testicular health caused by ethanol exposure.
Objective: Androgen deficiency is associated with multiple biochemical and behavioral disorders. This study investigated the effects of testosterone replacement and Spirulina Platensis association on testosterone deficiency-induced metabolic disorders and memory impairment.
Methods: Adult male rats were randomly and equally divided into four groups and received the following treatments for 20 consecutive days.
Article Synopsis
- Major depression may be linked to disruptions in the HPA axis and problems with neurogenesis in the hippocampus, which is important for the effects of antidepressants.
- This study used a mouse model to explore whether increasing adult hippocampal neurogenesis (AHN) after chronic stress could help alleviate behavioral deficits caused by stress.
- Results showed that enhancing AHN after 2 weeks of chronic stress improved certain behaviors and lowered stress hormone levels, suggesting a potential benefit of boosting neurogenesis in treating depression after stress exposure.
Article Synopsis
- - This study investigates how the hypothalamus-pituitary-adrenal (HPA) axis is linked to antidepressant resistance by creating a model of this condition in mice using Unpredictable Chronic Mild Stress (UCMS) over 9 weeks.
- - After a drug-free period, mice were tested for their ability to suppress corticosterone levels and divided into High suppression (HS) and Low suppression (LS) groups, with fluoxetine administered to assess its antidepressant effects.
- - Results indicated that fluoxetine was more effective in HS mice, as shown by behavioral tests and increased neuronal proliferation in the hippocampus, suggesting that low levels of cell proliferation might contribute to the antidepressant resistance seen in LS mice.
The aim of this study was to assess the potential subacute toxicity of zinc oxide (ZnO) nanoparticles (NPs) in Wistar rats in comparison with reference toxicant, zinc chloride (ZnCl2), of a non-nanoparticulate form. We therefore studied the relationships between zinc (Zn) accumulation, liver and kidney trace element levels, and plasmatic biochemical parameters. Rats in all groups were treated by intraperitoneal injection of ZnO NPs and/or ZnCl2 solution (25 mg/kg) every other day for 10 days.
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