Wastewater metagenomics in Africa: Opportunities and challenges.

The advent of metagenomics has dramatically expanded our understanding of microbial communities, particularly through the study of wastewater, which serves as a rich source of microbial data. In Africa, wastewater metagenomics presents unparalleled opportunities for public health monitoring, antimicrobial resistance (AMR) tracking, and the discovery of new microbial species and functions. Utilizing high-throughput sequencing (HTS) technologies, this method allows for direct analysis of nucleic acids from wastewater samples, providing a cost-effective and comprehensive approach for pathogen surveillance.

Navigating Sensor-Skin Coupling Challenges in Magnetic-Based Blood Pressure Monitoring: Innovations and Clinical Implications for Hypertension and Aortovascular Disease Management.

Non-invasive blood pressure monitoring has emerged as a critical frontier in cardiovascular healthcare, with magnetic sensors playing an increasingly pivotal role in wearable health technologies. This comprehensive review critically examines the complex challenges of sensor-skin coupling and its profound impact on the accuracy of blood pressure measurements in patients with hypertension and aortovascular disease. Despite the growing demand for precise, real-time health monitoring, significant limitations persist in current magnetic sensor technologies.

Estrogenized HSA induced high-affinity autoantibodies in breast cancer - Novel biomarker for early detection.

Objective: Breast cancer (BC) is the second most prevalent cancer worldwide. Estrogen has been increasingly recognized as a major contributor to the development of BC, playing a more critical role than previously understood. Estrogen derived nucleic acid and protein adducts have been shown to play significant roles in BC development and progression.