Publications by authors named "W Kevin Grace"

Plant polyphenols are bioactive compounds touted for their antioxidant effects, and this is often the primary attribute used to explain their health benefits. However, we hypothesize that polyphenols have molecular properties independent of antioxidant function. The objective of this study was to investigate whether polyphenols had distinct molecular effects compared to pure antioxidants.

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Article Synopsis
  • The American Society of Pain and Neuroscience (ASPN) recognizes a need for guidelines to help healthcare providers effectively use social media for best practices.
  • A panel of experts conducted research and analyzed literature to develop these best practices for healthcare professionals engaging online.
  • It's essential for providers to understand the impact of social media on patient perceptions and to navigate legal and ethical issues while maintaining a clear and educational online presence.
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Background: The objective of this prospective, multicenter study is to characterize responses to percutaneous medial branch peripheral nerve stimulation (PNS) to determine if results from earlier, smaller single-center studies and reports were generalizable when performed at a larger number and wider variety of centers in patients recalcitrant to nonsurgical treatments.

Materials & Methods: Participants with chronic axial low back pain (LBP) were implanted with percutaneous PNS leads targeting the lumbar medial branch nerves for up to 60 days, after which the leads were removed. Participants were followed long-term for 12 months after the 2-month PNS treatment.

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Introduction: Surgical site infection is a potential complication of spinal cord stimulator (SCS) implantation. Current understanding of the epidemiology, diagnosis, and treatment of these infections is based largely on small clinical studies, many of which are outdated. Evidence-based guidelines for management of SCS-related infections thus rely instead on expert opinion, case reports, and case series.

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Article Synopsis
  • Spinal cord stimulation is a recognized treatment for chronic pain but carries risks of complications, particularly infections, which this article aims to better understand by analyzing data from previous surgeries.
  • A review of 2737 spinal cord stimulator implants showed an overall infection rate of 2.45%, indicating a lower incidence compared to earlier studies, while examining various risk factors and preventative measures.
  • The study found that diabetes, tobacco use, and obesity did not significantly increase infection rates; however, using occlusive dressings and post-operative antibiotics were associated with lower infection rates.
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