Publications by authors named "W KLUG"
Background: Anaesthetic drugs may cause neuroapoptosis in children and are routinely used off-label in specific age groups. Techniques that reduce anaesthetic drug dose requirements in children may thus enhance the safety of paediatric sedation or anaesthesia. Brainwave entrainment, notably in the form of auditory binaural beats, has been shown to have sedative effects in adults.
View Article and Find Full Text PDFThe spindle-shaped virion morphology is common among archaeal viruses, where it is a defining characteristic of many viral families. However, structural heterogeneity intrinsic to spindle-shaped viruses has seriously hindered efforts to elucidate the molecular architecture of these lemon-shaped capsids. We have utilized a combination of cryo-electron microscopy and X-ray crystallography to study tailed spindle virus (ATSV).
View Article and Find Full Text PDFWe propose a hybrid discrete-continuum model to study the ground state of protein shells. The model allows for shape transformation of the shell and buckling transitions as well as the competition between states with different symmetries that characterize discrete particle models with radial pair potentials. Our main results are as follows.
View Article and Find Full Text PDFArticle Synopsis
- The study introduces a Landau theory focusing on large-l orientational phase transitions and its application to the assembly of icosahedral viral capsids.
- It identifies two types of ordering transitions: robust first-order transitions dominated by specific icosahedral spherical harmonics, and a more complex transition influenced by a mixture of l=15 and l=16, which is affected by chirality.
- The research emphasizes the competition between various symmetry states in viral capsids, using a group-theoretic approach to analyze these different symmetries.