Publications by authors named "W K Read"
Introgression - the exchange of genetic material through hybridization - is now recognized as common among animal species. The extent of introgression, however, can vary considerably even when it occurs: for example, introgression can be geographically restricted or so pervasive that populations merge. Such variation highlights the importance of understanding the factors mediating introgression.
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- Sarcomas developing in previously infarcted bones are rare, typically manifesting as undifferentiated pleomorphic sarcomas (UPS), with unclear genetic profiles and generally treated with surgery and chemotherapy.
- A study on 6 cases analyzed 523 genes for mutations using advanced genomic techniques, revealing significant complexity and high genomic instability, marked by alterations in chromosome 12 and common mutations in genes like MDM2 and CDKN2A/B.
- Findings indicated that these UPS tumors presented with high tumor mutational burden and significant genetic diversity, showing the potential for targeted therapies and emphasizing the need for further research in this area.
Introduction: Neurotoxicity is a well-documented side effect of ifosfamide chemotherapy. The presentation includes hallucinations, seizures, disorientation, coma, and death. Treatment with methylene blue can shorten the duration and severity of symptoms.
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- The Hunga Tonga-Hunga Ha'apai volcano erupted on January 15, 2022, providing a unique chance to study how tropical volcanic eruptions affect the stratosphere.
- Observations from balloons near Réunion Island indicated a significant injection of water vapor which led to increased humidity, causing rapid ozone depletion of 5% within a week.
- The study also showed changes in chlorine compounds in the volcanic plume, enhancing our understanding of volcanic impacts on stratospheric chemistry and potential climate change effects.
Background: Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a poor prognosis and no established therapy. Recently, encouraging responses to immune checkpoint inhibitors have been reported.
Methods: We conducted an investigator-initiated, multicenter, single-group, phase 2 study of the anti-programmed death ligand 1 (PD-L1) agent atezolizumab in adult and pediatric patients with advanced ASPS.